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They include the following: General fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating; Central Nervous System headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia; Musculoskeletal tremors, muscle weakness; Cardiovascular palpitations, tachycardia, arrhythmias, increased pulse and blood purchase pressure, heart failure, angina. Depressed cardiac function is also observed including most often bradycardia and hypotension. Tizanidine does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition. Doxycycline Hyclate online, you are ordering high quality, safe, and affordable prescription medication. You should not consume more than 15 mg (3 tablets) in a day. In these cases, your doctor may want to change the dose, or other precautions may be necessary. This was associated with an increase in side effects of tizanidine. 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